5.5.3. Synthetic tissues
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5.5.3. Synthetic tissues
Use the future to build the present
Synthetic tissues
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Stakeholder Type
1.1Advanced AI1.2QuantumRevolution1.3UnconventionalComputing1.4AugmentedReality1.5CollectiveIntelligence2.1CognitiveEnhancement2.2HumanApplicationsof GeneticEngineering2.3HealthspanExtension2.4ConsciousnessAugmentation2.5Organoids2.6FutureTherapeutics3.1Decarbonisation3.2EarthSystemsModelling3.3FutureFoodSystems3.4SpaceResources3.5OceanStewardship3.6SolarRadiationModification3.7InfectiousDiseases4.1Science-basedDiplomacy4.2Advancesin ScienceDiplomacy4.3Foresight,Prediction,and FuturesLiteracy4.4Democracy-affirmingTechnologies5.1ComplexSystemsScience5.2Futureof Education5.3Future Economics,Trade andGlobalisation5.4The Scienceof theOrigins of Life5.5SyntheticBiology
1.1Advanced AI1.2QuantumRevolution1.3UnconventionalComputing1.4AugmentedReality1.5CollectiveIntelligence2.1CognitiveEnhancement2.2HumanApplicationsof GeneticEngineering2.3HealthspanExtension2.4ConsciousnessAugmentation2.5Organoids2.6FutureTherapeutics3.1Decarbonisation3.2EarthSystemsModelling3.3FutureFoodSystems3.4SpaceResources3.5OceanStewardship3.6SolarRadiationModification3.7InfectiousDiseases4.1Science-basedDiplomacy4.2Advancesin ScienceDiplomacy4.3Foresight,Prediction,and FuturesLiteracy4.4Democracy-affirmingTechnologies5.1ComplexSystemsScience5.2Futureof Education5.3Future Economics,Trade andGlobalisation5.4The Scienceof theOrigins of Life5.5SyntheticBiology

Sub-Field:

5.5.3Synthetic tissues

    Synthetic biology can be used to engineer multiple cells, creating artificial tissues such as muscle and organs.21

    These synthetic tissues and organs could be used in place of donor organs for transplants. If they were produced using the recipient's own cells, the risk of rejection would be greatly reduced. Progress is being made: for example, mouse ovaries have been successfully 3D printed and implanted into sterilised mice, restoring ovarian function.22 The hope is that similar technologies can ultimately be used in humans.

    A related field aims to trigger tissue regeneration to heal severe injuries, avoiding the need for a full transplant by instead inducing the damaged organ to repair itself.23 Some human tissues naturally regenerate, notably the liver, but not all --- and controlling the process remains a considerable challenge.24

    Artificial tissue is also being explored for the production of cruelty-free "meat" by culturing animal cells. So far, the artificial meats on the market resemble processed meats, such as burgers or mince. The next step is to recreate the complex three-dimensional structure of a cut such as a steak. This requires tissues that contain multiple cell types, correctly organised in space, and remains some way off.25

    Future Horizons:

    ×××

    5-yearhorizon

    High-throughput tissue production begins

    Automation, AI-driven standardised protocols and better tissue culture media enable high-throughput tissue production. Artificial meat derived from fungi becomes mainstream in the food marketplace.

    10-yearhorizon

    Accelerated evolution becomes possible

    Manipulation of chromosomes and stem cells accelerates evolution for research purposes, and "microphysical systems" of cells and bioreactors become a ubiquitous research tool. Cultured steak has become indistinguishable from the real thing.

    25-yearhorizon

    Breakthroughs benefit food, fashion and transplant surgery

    The fashion industry embraces synthetically engineered fake leather. Programmable stem cells produce organs for human transplants. The food industry uses biomanufacturing techniques to make non-animal meat at scale, helping to achieve better nutrition.

    Synthetic tissues - Anticipation Scores

    How the experts see this field in terms of the expected time to maturity, transformational effect across science and industries, current state of awareness among stakeholders and its possible impact on people, society and the planet. See methodology for more information.