5.5.4. Synthetic multicellular organisms
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5.5.4. Synthetic multicellular organisms
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Synthetic multicellular organisms
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1.1Advanced AI1.2QuantumRevolution1.3UnconventionalComputing1.4AugmentedReality1.5CollectiveIntelligence2.1CognitiveEnhancement2.2HumanApplicationsof GeneticEngineering2.3HealthspanExtension2.4ConsciousnessAugmentation2.5Organoids2.6FutureTherapeutics3.1Decarbonisation3.2EarthSystemsModelling3.3FutureFoodSystems3.4SpaceResources3.5OceanStewardship3.6SolarRadiationModification3.7InfectiousDiseases4.1Science-basedDiplomacy4.2Advancesin ScienceDiplomacy4.3Foresight,Prediction,and FuturesLiteracy4.4Democracy-affirmingTechnologies5.1ComplexSystemsScience5.2Futureof Education5.3Future Economics,Trade andGlobalisation5.4The Scienceof theOrigins of Life5.5SyntheticBiology
1.1Advanced AI1.2QuantumRevolution1.3UnconventionalComputing1.4AugmentedReality1.5CollectiveIntelligence2.1CognitiveEnhancement2.2HumanApplicationsof GeneticEngineering2.3HealthspanExtension2.4ConsciousnessAugmentation2.5Organoids2.6FutureTherapeutics3.1Decarbonisation3.2EarthSystemsModelling3.3FutureFoodSystems3.4SpaceResources3.5OceanStewardship3.6SolarRadiationModification3.7InfectiousDiseases4.1Science-basedDiplomacy4.2Advancesin ScienceDiplomacy4.3Foresight,Prediction,and FuturesLiteracy4.4Democracy-affirmingTechnologies5.1ComplexSystemsScience5.2Futureof Education5.3Future Economics,Trade andGlobalisation5.4The Scienceof theOrigins of Life5.5SyntheticBiology

Sub-Field:

5.5.4Synthetic multicellular organisms

    Creating wholly synthetic multicellular organisms is probably synthetic biology's greatest technical challenge. The limiting factor in creating engineered multicellular organisms is the ability to write or assemble larger genomes, be they for animals, fungi, or plants, or completely novel creatures.

    Much of the work on artificial multicellular organisms is at an early stage and the end results are not predictable. One prominent line of work involves "xenobots", which are tiny artificial organisms — or alternatively, biological robots.26 These are not strictly synthetic, since they are derived from largely unengineered stem cells obtained from the developing embryos of Xenopus frogs. Existing xenobots only include two cell types: skin cells to provide structure and heart cells that act as motors. Nevertheless they can already perform a range of functions including swimming or rowing (using cilia as oars) through fluids. Xenobots may find uses as drug delivery mechanisms, or disposing of pollutants by swarming and trapping them.

    More likely in the short to medium term is increasing applications for multicellular organisms which have been modified in a number of ways. For example, multicellular organisms created using genetic engineering fall into this category.

    The first genetically-modified organisms (GMOs) were produced using quite crude methods — for example, inserting a single gene into a random place in the genome. The products of this technology nonetheless have considerable potential: for example, “golden rice”, engineered to produce a precursor to vitamin A, has the potential to alleviate vitamin A deficiency, which can causes serious vision problems and is common in parts of the Global South.27 Nowadays, modern genome editing tools like CRISPR-Cas allow much more precise and targeted genetic alterations, such as rewriting a few "letters" within a gene.28

    The engineering of multicellular organisms may also have a role to play in conservation biology.29 For example, it is possible to engineer threatened species to resist diseases that would otherwise contribute to their extinction. American chestnut trees have been genetically engineered to resist the chestnut blight fungus, which nearly wiped out the species over the last century.30 The tools of synthetic biology may also be brought to bear to revive species that are otherwise effectively extinct, such as the northern white rhino.31

    Future Horizons:

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    5-yearhorizon

    Smart microbiomes come of age

    Smart microbiomes, essentially logic-based synthetic gene circuits, are developed. These sense and respond to stimuli within a multicellular host. Research creates precision hybrids that combine traits of two related species. Policymakers develop regulations for gene-edited staple crops that can withstand climate-induced changes in their environment.

    10-yearhorizon

    Engineering benefits corals

    Corals benefit from engineered protection. Research shortens the timescales for coral reef regeneration and renewal. Large-scale rewriting of genotypes for a variety of applications becomes possible, thanks to advances in synthetic genomics and stem cell technology. Invasive species, disease vectors and agricultural pests are significantly reduced thanks to the development of synthetic biocontrol agents. Engineered multi-cellular systems offer a novel approach to logic and computation.

    25-yearhorizon

    Some lost biodiversity restored

    Artificial chromosomes, preloaded with genes for medications etc, can be uploaded into humans. Some lost biodiversity is restored through synthetic biology techniques, and the Earth hosts the first "synthetic ecosystems", in which many species have been altered or synthesised from scratch.

    Synthetic multicellular organisms - Anticipation Scores

    How the experts see this field in terms of the expected time to maturity, transformational effect across science and industries, current state of awareness among stakeholders and its possible impact on people, society and the planet. See methodology for more information.

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