5.5.2. Synthetic cells
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5.5.2. Synthetic cells
Use the future to build the present
Synthetic cells
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1.1Advanced AI1.2QuantumRevolution1.3UnconventionalComputing1.4AugmentedReality1.5CollectiveIntelligence2.1CognitiveEnhancement2.2HumanApplicationsof GeneticEngineering2.3HealthspanExtension2.4ConsciousnessAugmentation2.5Organoids2.6FutureTherapeutics3.1Decarbonisation3.2EarthSystemsModelling3.3FutureFoodSystems3.4SpaceResources3.5OceanStewardship3.6SolarRadiationModification3.7InfectiousDiseases4.1Science-basedDiplomacy4.2Advancesin ScienceDiplomacy4.3Foresight,Prediction,and FuturesLiteracy4.4Democracy-affirmingTechnologies5.1ComplexSystemsScience5.2Futureof Education5.3Future Economics,Trade andGlobalisation5.4The Scienceof theOrigins of Life5.5SyntheticBiology
1.1Advanced AI1.2QuantumRevolution1.3UnconventionalComputing1.4AugmentedReality1.5CollectiveIntelligence2.1CognitiveEnhancement2.2HumanApplicationsof GeneticEngineering2.3HealthspanExtension2.4ConsciousnessAugmentation2.5Organoids2.6FutureTherapeutics3.1Decarbonisation3.2EarthSystemsModelling3.3FutureFoodSystems3.4SpaceResources3.5OceanStewardship3.6SolarRadiationModification3.7InfectiousDiseases4.1Science-basedDiplomacy4.2Advancesin ScienceDiplomacy4.3Foresight,Prediction,and FuturesLiteracy4.4Democracy-affirmingTechnologies5.1ComplexSystemsScience5.2Futureof Education5.3Future Economics,Trade andGlobalisation5.4The Scienceof theOrigins of Life5.5SyntheticBiology

Sub-Field:

5.5.2Synthetic cells

    The next scale up is engineered single cells, where the end product is the cells themselves.15 In one dramatic example, a microorganism had its entire genome removed and replaced with an artificial one, which then "booted up" inside the cell.16

    Engineered microorganisms can be put to work in a range of fields. For example, they may well play a role in mitigating the impacts of climate change by removing carbon dioxide from the atmosphere: large-scale algae farms are one of the most effective forms of CO2 removal, and synthetic biologists can optimise the algae's ability to take up the greenhouse gas.17

    Cells can also be engineered to act as sensors that can detect threats. Such biosensors may be used to scan for pollutants such as heavy metals or even the explosive (or its breakdown products) leaking out from buried landmines.18 Similar biosensors have been designed to detect pathogens or signs of disease such as cancer. In future some of these may be engineered into wearable forms: for example, facemasks that detect the presence of the SARS-CoV-2 virus.19

    A related field focuses on engineering viruses. By their nature, viruses inject their own DNA into the cells of the organisms they infect. Medical researchers are harnessing this capability to create viruses that fix the genetic defects that lead to severe diseases like severe combined immunodeficiency (SCID), also known as "bubble boy disease".20

    Future Horizons:

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    5-yearhorizon

    AI and molecular electronics aid engineering

    AI guides the re-engineering of cellular systems, while applications for commercial molecular electronics --- such as in environmental monitoring --- proliferate, allowing engineered molecules that emit electrical signals in response to environmental cues to be integrated into electronics as novel sensors.

    10-yearhorizon

    Cell self-assembly becomes possible

    It becomes possible to "boot" an engineered genome to start a process leading to self-assembly in a reproductive cell. Artificial organelles find commercial applications for drug activation and as biochemical reactors.

    25-yearhorizon

    Artificial photosynthesis begins

    Energy is generated through artificial photosynthesis, and microorganism-based petrochemical manufacturing platforms become commonplace. In the labs, researchers work with a whole-cell model that can be cheaply tinkered with. The first synthetic extremophiles are sent into space as part of a mission to Mars.

    Synthetic cells - Anticipation Scores

    How the experts see this field in terms of the expected time to maturity, transformational effect across science and industries, current state of awareness among stakeholders and its possible impact on people, society and the planet. See methodology for more information.

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