2.1.3. Neuromodulation systems
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2.1.3. Neuromodulation systems
Use the future to build the present
Neuromodulation systems
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1.1Advanced AI1.2QuantumRevolution1.3UnconventionalComputing1.4AugmentedReality1.5CollectiveIntelligence2.1CognitiveEnhancement2.2HumanApplicationsof GeneticEngineering2.3HealthspanExtension2.4ConsciousnessAugmentation2.5Organoids2.6FutureTherapeutics3.1Decarbonisation3.2EarthSystemsModelling3.3FutureFoodSystems3.4SpaceResources3.5OceanStewardship3.6SolarRadiationModification3.7InfectiousDiseases4.1Science-basedDiplomacy4.2Advancesin ScienceDiplomacy4.3Foresight,Prediction,and FuturesLiteracy4.4Democracy-affirmingTechnologies5.1ComplexSystemsScience5.2Futureof Education5.3Future Economics,Trade andGlobalisation5.4The Scienceof theOrigins of Life5.5SyntheticBiology
1.1Advanced AI1.2QuantumRevolution1.3UnconventionalComputing1.4AugmentedReality1.5CollectiveIntelligence2.1CognitiveEnhancement2.2HumanApplicationsof GeneticEngineering2.3HealthspanExtension2.4ConsciousnessAugmentation2.5Organoids2.6FutureTherapeutics3.1Decarbonisation3.2EarthSystemsModelling3.3FutureFoodSystems3.4SpaceResources3.5OceanStewardship3.6SolarRadiationModification3.7InfectiousDiseases4.1Science-basedDiplomacy4.2Advancesin ScienceDiplomacy4.3Foresight,Prediction,and FuturesLiteracy4.4Democracy-affirmingTechnologies5.1ComplexSystemsScience5.2Futureof Education5.3Future Economics,Trade andGlobalisation5.4The Scienceof theOrigins of Life5.5SyntheticBiology

Sub-Field:

2.1.3Neuromodulation systems

    A wide variety of interventions can change cognitive function. Some are behavioural, including exercise, meditation, sleep hygiene or cognitive training. More targeted approaches include drugs and nutritional supplements, such as the attention-boosting drugs methylphenidate and modafinil, initially developed to treat cognition-limiting disorders. At present, however, the most widely discussed strategies involve brain stimulation via electromagnetic fields: transcranial magnetic stimulation (TMS), transcranial direct current stimulation (tDCS) and Deep Brain Stimulation (DBS).

    tDCS and TMS have been shown to enhance certain cognitive functions, such as episodic memory in older adults.1415 DBS, which has been successful for Parkinson’s and obsessive-compulsive disorder, has also alleviated some symptoms of Alzheimer’s disease in some participants in a small clinical trial.16 Other penetrating electrical brain implants are mooted to provide prosthetic memories for people with traumatic brain injuries.17

    Further progress will come with “adaptive closed-loop systems”. These can read and decode brain signals, and respond by making decisions — often aided by AI — to engage stimulation in order to override, dampen or amplify a particular signal.18 Better materials19 and implantation devices and methods are also in the works; Neuralink, for instance, recently announced that it has earned FDA approval to trial its implants in humans.20

    Future Horizons:

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    5-yearhorizon

    Brain stimulation devices proliferate

    Next-generation implants like Neuralink are in human trials, allowing for simultaneous recording and stimulation in multiple regions across the brain. More electrode designs are approved for use in humans, including Stentrodes21 and Neuropixels.22 A DBS trial for Alzheimer’s sheds light on which brain areas are best for implantation. Edge computing aids processing on closed loop devices, hastening the acquisition of clinical neurological data. Wearable EEG devices enhance the depth and quality of sleep.

    10-yearhorizon

    Miniaturisation drives wider adoption of cognitive modulation

    Aided by AI, miniaturisation and brain-based chip design, safer closed-loop implanted devices treat an increasing variety of diseases including depression. It becomes possible to identify areas of the brain where electrical stimulation gives healthy people a boost in memory capacity. Epigenome editing alters brain function, helping damp the effects of trauma, for example.

    25-yearhorizon

    The era of high-precision genetic brain enhancement arrives

    Optogenetics allows manipulation of specific networks and types of human memory with high resolution and precision. AI enables tailored epigenome editing in the brain to remove barriers to optimal cognition. Genetic technologies begin to improve memory and other cognitive functions and reduce the cognitive decline associated with ageing.

    Neuromodulation systems - Anticipation Scores

    How the experts see this field in terms of the expected time to maturity, transformational effect across science and industries, current state of awareness among stakeholders and its possible impact on people, society and the planet. See methodology for more information.

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