Use the future to build the present
Fundamental Geroscience
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1Quantum Revolution& Advanced AI2HumanAugmentation3Eco-Regeneration& Geo-Engineering4Science& Diplomacy1.11.21.31.42.12.22.32.43.13.23.33.43.54.14.24.34.44.5HIGHEST ANTICIPATIONPOTENTIALAdvancedArtificial IntelligenceQuantumTechnologiesBrain-inspiredComputingBiologicalComputingCognitiveEnhancementHuman Applications of Genetic EngineeringRadical HealthExtensionConsciousnessAugmentation DecarbonisationWorldSimulationFuture FoodSystemsSpaceResourcesOceanStewardshipComplex Systems forSocial EnhancementScience-basedDiplomacyInnovationsin EducationSustainableEconomicsCollaborativeScience Diplomacy
1Quantum Revolution& Advanced AI2HumanAugmentation3Eco-Regeneration& Geo-Engineering4Science& Diplomacy1.11.21.31.42.12.22.32.43.13.23.33.43.54.14.24.34.44.5HIGHEST ANTICIPATIONPOTENTIALAdvancedArtificial IntelligenceQuantumTechnologiesBrain-inspiredComputingBiologicalComputingCognitiveEnhancementHuman Applications of Genetic EngineeringRadical HealthExtensionConsciousnessAugmentation DecarbonisationWorldSimulationFuture FoodSystemsSpaceResourcesOceanStewardshipComplex Systems forSocial EnhancementScience-basedDiplomacyInnovationsin EducationSustainableEconomicsCollaborativeScience Diplomacy

Sub-Field:

2.3.2Fundamental Geroscience

The emerging research consensus is that ageing is driven by several different interacting processes.11,12 These interlinked pathways influence the diseases of ageing in such a way that finding the right lever could likely defeat multiple causes of morbidity.
In the longer term, researchers aim to re-appraise the fundamental process and its mechanics. Recent evidence suggests that the fundamental upper limit for human age is around 120,13 but the question of what determines this; why it differs from other species, and whether drugs modify it remain open. Trials are currently illuminating some ageing mechanisms. Among those mechanisms are age-related dysregulation of metabolism, age-related disruption of adult stem cell function and an age-related increase in the number of senescent cells, which among other events drives an increase in chronic inflammation. Multi-morbidity studies are now planned to test whether alteration of a single pathway, such as metabolism or cell senescence, can ameliorate or prevent multiple diseases of age. This vision for geroscience goes far beyond treating old people: recent research suggests that the same pathways are involved in a variety of conditions, for example pre-eclampsia, accelerated ageing after childhood cancer treatment and radiation effects in space.

Future Horizons:

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5-yearhorizon

Better models of ageing emerge

Research begins to elucidate the dynamics of the interplay between the processes of ageing, and the knowledge gained is used to develop multiscale network models that incorporate the relevant physiological changes.

10-yearhorizon

Ageing is integrated into healthcare as a treatable disease process

Insights into the epigenetic changes that happen after taking certain drugs, such as metformin, enable us to hone our therapeutic approaches. Health plans begin to prescribe them. Trials to identify certain hallmarks of age — frailty, for example — yield useful results.

25-yearhorizon

Genetic insights begin to shed light on ageing

Machine learning algorithms help to identify the genes involved in healthy or less healthy ageing.

Fundamental Geroscience - Anticipation Scores

How the experts see this field in terms of the expected time to maturity, transformational effect across science and industries, current state of awareness among stakeholders and its possible impact on people, society and the planet. See methodology for more information.

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