Nevan Krogan uses large-scale genetics and biochemistry to define the interactions among genes and proteins that govern cell functions in health and disease. Combining bench work with computer science, his lab identifies molecular networks acting inside cells and shows how these networks respond to disease-causing mutations or infection by pathogens. Thanks to their ability to survey a cell’s complete set of genes and proteins, Krogan and his team generate novel mechanistic insights into cell biology as well as potential targets for novel therapies. Krogan’s lab is applying this unbiased approach to a number of conditions, including infectious diseases such as COVID-19, cancer and heart disease.