Whether for medical technologies such as diagnostic imaging, surgical intervention, prevention of infectious disease outbreaks and cancer treatment, or for biological applications in neuroscience, genomics and improving agricultural practices, mathematics plays a central role in our study of living systems. Where is the most urgent need for mathematical innovation in our interactions with biology? How can mathematics, suitably applied, have a greater impact on healthcare, agriculture and ecological concerns? What will be the relevant mathematical breakthroughs of the next 5, 10 and 25 years that impact our understanding and interactions with biology from cellular to ecosystem level?